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SARS-CoV-2 progenitor bat viruses genetically close to SARS-CoV-2 and able to enter human cells through a human ACE2 (hACE2) pathway have not yet been identified, although they would be key in understanding the origin of the epidemic.
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The spike sequence determines the binding affinity and accessibility of its receptor-binding domain to the cellular angiotensin-converting enzyme 2 (ACE2) receptor and is responsible for host range 10, 11, 12. SARS-CoV-2 has a mosaic genome, to which different progenitors contribute. The animal reservoir of SARS-CoV-2 is unknown despite reports of SARS-CoV-2-related viruses in Asian Rhinolophus bats 1, 2, 3, 4, including the closest virus from R. Nature volume 604, pages 330–336 ( 2022) Cite this article Bat coronaviruses related to SARS-CoV-2 and infectious for human cells